Authors:

Wall EC, Gordon SB, Hussain S, Goonetilleke UR, Gritzfeld J, Scarborough M, et al.

Abstract:

Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.

Journal:

Clinical Infectious Diseases

Year:

2012

PMID:

22238165

PMCID:

PMC3275762

Hyperlink:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275762/