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Dr Jamie Rylance

 Jamie Rylance 000 1

Jamie's Clinical PhD Programme Experience:

"I applied for a research fellowship so that I could take responsibility for my own work and direction. The latitude for developing ideas, and the strong support from supervisors and colleagues helped me develop a project which was interesting and relevant to major global health challenges. I’ve been examining the effect of household air pollution on the lung health of people in Malawi, and by extension that of the 3 billion people affected worldwide. Having completed the lab work, I’m now concentrating on writing up the results for peer-review, and developing the collaborations our group has fostered over the four year fellowship.

Living and working abroad has been exciting, different and challenging. Being able to take on senior and mentoring roles in Malawi has benefitted me, and (I hope) some of the people who I have supervised; junior doctors, laboratory technicians, research nurses. My most memorable moments will be of these people. But, as a close second, the moments in the laboratory where everything has worked, results look good, and there is a tantalising moment when you might fairly say “I’ve discovered something!”. For me, this was explaining the defective behaviour of innate immune cells which have been exposed to particulates from household air pollution.

I’ve now secured a Clinical Lecturer post which gives me the ability to develop this research, and to complete higher specialist medical training. I plan to use this time to apply for a further fellowship award."

 

Publications for Jamie Rylance

Publication Household air pollution causes dose-dependent inflammation and altered phagocytosis in human macrophages.
2015
Rylance J, Fullerton DG, Scriven J, Aljurayyan AN, Mzinza D, Barrett S, Wright AK, Wootton DG, Glennie SJ, Baple K, Knott A, Mortimer K, Russell DG, Heyderman RS, Gordon SB.


Publication Are we failing our trainees in providing opportunities to attain procedural confidence?
2015
Lagan J, Cutts L, Zaidi S, Benton I, Rylance J.


Publication Chronic Household Air Pollution Exposure Is Associated with Impaired Alveolar Macrophage Function in Malawian Non-Smokers.
2015
Rylance J, Chimpini C, Semple S, Russell DG, Jackson MJ, Heyderman RS, Gordon SB.


Publication Clinical Characteristics and Lung Function in Older Children Vertically Infected With Human Immunodeficiency Virus in Malawi.
2015
Mwalukomo T, Rylance SJ, Webb EL, Anderson S, O'Hare B, van Oosterhout JJ, Ferrand RA, Corbett EL, Rylance J.


Publication Comparison of methods for the analysis of airway macrophage particulate load from induced sputum, a potential biomarker of air pollution exposure.
2015
H, Rylance J, Patel L, Gordon SB, Mortimer K


Publication Pneumonia severity scores in resource poor settings.
2014
Rylance J, Waitt P


Publication Respiratory risks from household air pollution in low and middle income countries.
2014
Gordon SB, Bruce NG, Grigg J, Hibberd PL, Kurmi OP, Lam KB, Mortimer K, Asante KP, Balakrishnan K, Balmes J, Bar-Zeev N, Bates MN, Breysse PN, Buist S, Chen Z, Havens D, Jack D, Jindal S, Kan H, Mehta S, Moschovis P, Naeher L, Patel A, Perez-Padilla R, Pope D, Rylance J, Semple S, Martin WJ 2nd


Publication Household Air Pollution Causes Dose-dependent Inflammation and Altered Phagocytosis in Human Macrophages.
2014
Rylance J, Fullerton DG, Scriven J, Aljurayyan AN, Mzinza D, Barrett S, Wright AK, Wootton DG, Glennie SJ, Baple K, Knott A, Mortimer K, Russell DG, Heyderman RS, Gordon SB.


Publication Bronchoalveolar lavage (BAL) for research; obtaining adequate sample yield.
2014
Collins AM, Rylance J, Wootton DG, Wright AD, Wright AK, Fullerton DG, Gordon SB.


Publication Immunoactivating Peptide p4 augments alveolar macrophage phagocytosis in two diverse human populations
2013
Bangert M, Wright AK, Rylance J, et al.


Publication Sickle-cell disease in Malawian children is associated with restrictive spirometry: a cross-sectional survey
2013
Cook J, Jefferis O, Matchere P, Mbale E, Rylance J.


Publication Household air pollution: a call for studies into biomarkers of exposure and predictors of respiratory disease
2013
Rylance J, Gordon SB, Naeher LP, et al


Publication Early warning scores generated in developed healthcare settings are not sufficient at predicting early mortality in Blantyre, Malawi: a prospective cohort study
2013
Wheeler I, Price C, Sitch A, Banda P, Kellett J, Nyirenda M, Rylance J


Publication Acute exposure of mice to high-dose ultrafine carbon black decreases susceptibility to pneumococcal pneumonia
2010
Tellabati A, Fernandes VE, Teichert F, Singh R, Rylance J, Gordon S, et al.


Publication Priorities for tuberculosis research: a systematic review
2010
Rylance J, Pai M, Lienhardt C, Garner P


Prizes:

University poster presentations - Highly Commended, University of Liverpool, 2010
Young Investigator Award from CROI 2012